The difference between the artificial and the artful in the artistic lies on the surface in the former there… — John Dewey
The difference between the artificial and the artful in the artistic lies on the surface in the former there is a split between what is overly done and what is intended. The appearance is one of cordiality; the intent is that of gaining favor. Whenever this split between what is done and its purpose exists, there is insincerity, a trick, a simulation of an act that intrinsically has another effect. When the natural and the cultivated blend into one, acts of social intercourse are works of art. The animating impulsion of genial friendship and the deed performed completely coincide without intrusion of ulterior motive. Awkwardness may prevent adequacy of expression.
Source: Wikiquote · CC BY-SA 4.0
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Coleridge said that every work of art must have about it something not understood to obtain its full effect.
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The true antithesis of nature is not art but arbitrary conceit, fantasy, and stereotyped convention.
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When there is genuine artistry in scientific inquiry and philosophic speculation, a thinker proceeds neither by rule nor yet blindly, but by means of meaning that exist immediately as feelings having qualitative color.

